Friday, April 18th, 2014

Intracranial electrophysiology (ICE) electrodes inside cranium, to guide surgery

Composite x-ray (face swapped), for patient's privacy. Connectors (upper right) lead to computer.

Intracranial electrophysiology (ICE) electrodes inside cranium, to guide surgery Intracranial electrophysiology (ICE) electrodes inside cranium, to guide surgery

ICE data allow us to localize dipoles in time and within gyral convolution

Bipolar and reconstructed monopolar field lines lead to a detailed dipole model.

ICE data allow us to localize dipoles in time and within gyral convolution ICE data allow us to localize dipoles in time and within gyral convolution

Placement of electrodes across cortex and averaged spectral power from each

Example electrode placement (see MRI), and time-frequency ICE data at each site (color rasters).

Placement of electrodes across cortex and averaged spectral power from each Placement of electrodes across cortex and averaged spectral power from each

Subdural electrodes that are implanted on brain surface

Grid macro-electrodes of the type sometimes place in our patients. Images: AdTechMedical.com.

Subdural electrodes that are implanted on brain surface Subdural electrodes that are implanted on brain surface

Reliability of the three electrophysiological components of grammatical inflection

Triphasic response in ICE data is consistent and statistically reliable across and within patients.

Reliability of the three electrophysiological components of grammatical inflection Reliability of the three electrophysiological components of grammatical inflection

fMRI of the word reading and production nework

fMRI maps of regions engaged to read words and put in grammatical context. Click for more.

fMRI of the word reading and production nework fMRI of the word reading and production nework

Picture of brain cells talking: Inter-region phase locking

Phase-locking between two sets of brain cells, suggests long-distance white matter connection.

Picture of brain cells talking: Inter-region phase locking Picture of brain cells talking: Inter-region phase locking

ICE data from multiple electrodes in one patient’s brain

Evoked potentials and spectral power. Electrodes ordered vertically by when first activity began.

ICE data from multiple electrodes in one patient’s brain ICE data from multiple electrodes in one patient's brain

Intrancranial Electrophysiology (ICE): Three-Stage Response in Broca’s area

Discovery: small brain region process 3 different types of info at 3 different times, in 1/4 second.

Intrancranial Electrophysiology (ICE): Three-Stage Response in Broca’s area Intrancranial Electrophysiology (ICE): Three-Stage Response in Broca's area

Spectral analysis of ICE data recorded from V1

Time-Frequency plot of neural response to reading words in order to speak them. (c) Ned T. Sahin

Spectral analysis of ICE data recorded from V1 Spectral analysis of ICE data recorded from V1

Reconstructed MRI Showing 3D Brain Surface

Left lateral surface of the human brain (including Broca's area). See your own brain - participate!

Reconstructed MRI Showing 3D Brain Surface Reconstructed MRI Showing 3D Brain Surface